Clinically-backed ingredients
Boswellia Serrata [30% AKBA]
Willow Bark Extract [50% Salicin]
CELLg8®
Ginger Extract [20% Gingerol]
Boron
Magnesium
Boswellia Serrata [30% AKBA]
Targets the leukotriene inflammation pathway.
AKBA (acetyl-11-keto-β-boswellic acid) is the most active compound in Boswellia serrata, working by inhibiting 5-lipoxygenase (5-LOX) — an enzyme central to leukotriene production and joint inflammation. A randomized double-blind clinical trial found that Boswellia supplementation significantly reduced joint pain and stiffness, with enhanced-bioavailability formulations delivering superior results.*
Willow Bark Extract [50% Salicin]
Nature's original pain relief compound.
Willow bark contains salicin, a natural precursor to salicylic acid that supports a balanced inflammatory response by downregulating TNF-α and NF-κB. A meta-analysis of 6 randomized controlled trials involving 329 arthritis patients found significant improvements in pain relief and physical function compared to placebo.*
CELLg8®
Highly bioavailable joint inflammation support.
Cellg8® is a patented, lipid-based turmeric extract formulated for significantly enhanced curcuminoid absorption compared to standard extracts. Curcumin works by modulating NF-κB and 5-LOX signaling pathways — key drivers of joint inflammation. Research published in PMC found that curcumin and boswellic acids act synergistically to reduce inflammation and joint pain, with enhanced-bioavailability formulations outperforming standard extracts.*
Ginger Extract [20% Gingerol]
Dual-action enzyme inflammation inhibitor.
Gingerols, the active compounds in ginger extract, inhibit both COX and 5-LOX inflammatory enzymes — a dual mechanism that makes it particularly effective for joint support. Studies published in PubMed support ginger's role in reducing exercise-induced muscle soreness and supporting healthy inflammatory balance in joints.*
Boron
Essential mineral for joint health.
Boron plays a key role in supporting the metabolism of calcium, magnesium, and vitamin D — all critical for joint and bone health. Research suggests populations with higher dietary boron intake have lower rates of arthritis, and boron may help modulate inflammatory cytokines that drive joint degradation.*
Magnesium
Supports muscle recovery and relaxation.
Magnesium supports over 300 enzymatic reactions and plays a direct role in muscle relaxation and joint tissue recovery. Deficiency is common in active individuals and has been linked to increased inflammation and slower post-exercise recovery.*
How It Works Over Time
Results you can feel in as little as 7 days.*
- Discomfort begins to ease
- Stiffness starts to reduce
- Your joints feel the difference
- Mobility improves
- Movement feels more fluid
- Recovery gets easier
- Full support kicks in
- Joints feel strong and flexible
- You move like you used to
How to Use:
- Take 2 capsules daily, with or without food, day or night.
Guaranteed results, or your money back
All Primonutra products come with a money back guarantee. If you don't feel a noticeable improvement within 90 days, we'll refund you for your entire purchase.
Frequently Asked Questions
Who should take Soothe?
Soothe is ideal for anyone experiencing joint discomfort, stiffness, or inflammation. It’s perfect for active individuals, aging adults, or anyone looking to maintain joint health and mobility.
How is Soothe different from other joint supplements?
Soothe stands out with its highly bioavailable ingredients, small-batch production for quality assurance, and a focus on targeting the root cause of joint issues—such as inflammation and cartilage support—not just masking symptoms.
Can Soothe be taken long-term?
Yes, Soothe is designed for ongoing support and maintenance of joint health. Regular use helps sustain results and protects your joints as you age or remain active.